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In the last decades, several Authors reports the widespread use of plant derivatives as pharmaceutical grades nutrients. Glucosamine and chondroitin sulfate synergistically contribute to cartilage formation and repair they also decrease the signs of pain associated with OA. Nutraceuticals are natural supplements widely used in veterinary medicine as a multimodal treatment of OA. The NSAIDs effectively relieve the pain in canine OA, even if related long-term use side effects (e.g., duodenal ulcers, acute renal failure, increased enzyme activities) reduce the safety usage of these drugs. There is no specific OA treatment multimodal management, including Non-steroidal anti-inflammatory drugs (NSAIDs) and nutraceuticals, is the preferred approach. In the late stage of the disease, chronic neuropathic pain leads to reduced quality-of-life of affected dogs. Д¬linical signs of OA are lameness, stiffness, loss of joint function, and mobility. The OA should be considered a final common pathway of joint damage secondary to a multitude of inciting events, many of which may also be unrecognized. ДЄging alone is an unlikely cause of OA: in veterinary literature, it has been suggested that 20% of dogs above one year old are affected by the progressive changes of OA. Osteoarthritis (OA) is a slowly progressive disease characterized by articular cartilage degradation, subchondral bone sclerosis, periarticular proliferation of new bone, and chronic inflammation of synovial membrane. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

There are no additional products in development or marketed products to declare. curcuVet is contained in a dietetic complementary feed produced by Aurora Biofarma, so-called Lecurpet. curcuVet is a registered march (Indena s.p.a., Milan, Italy). No patented products in development are present in this study.

The funders had no additional role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Д¬ompeting interests: AN is a scientific consultant of Aurora Biofarma and receives funding in the form of salary. The specific roles of this author are articulated in the вЂauthor contributionsвЂ™ section. Aurora Biofarma provided support in the form of nutraceutical preparation and in the form of salary to AN. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Дata Availability: All relevant data are within the manuscript.ДЇunding: AN is a scientific consultant of Aurora Biofarma. Received: MaAccepted: Published: May 28, 2021Д¬opyright: В© 2021 Caterino et al. PLoS ONE 16(5):Д®ditor: Ewa Tomaszewska, University of Life Sciences in Lublin, POLAND (2021) Clinical efficacy of Curcuvet and Boswellic acid combined with conventional nutraceutical product: An aid to canine osteoarthritis. Citation: Caterino C, Aragosa F, Della Valle G, Costanza D, Lamagna F, Piscitelli A, et al.

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